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Opening of the London Calling conference by Oxford Nanopore; between a diversity of innovative research, the development of human genomics and cancer
Conference presentations will highlight the usefulness of comprehensive genomic research nanopore sequencing for new discoveries in human genetics, cancer research, conservation, pathogen genomics, and more.
OXFORD, UK / ACCESSWIRE / May 19, 2022 / The annual London Calling genomics conference, organized through Oxford Nanopore, begins today with more than 80 clinical meetings in one of the disciplines, expected to be attended by thousands of scientists as a user or online.
More and more researchers are applying Oxford Nanopore sequencing generation to human and cancer genomics to make new discoveries. This new wisdom fuels fundamental and translational studies and will have prospective use in health care in the future. It targets single-nucleotide (SNP) and indel (inserted or removed bases) polymorphisms, but now nanopore sequencing supports the discovery of the genetic underpinnings of disease, enabling functional genomics and new biomarker discoveries. In addition, thanks to the functions of simultaneous genomic and epigenomic studies of the local DNA of nanopore sequencing, it is now also imaginable as it should be and simultaneously stumble upon structural variants (SV), copy number variants (CNV) and methylation at the solved haplotype level.
The studies presented this week demonstrate the clinical price of characterizing these richer data and point to an expansion of the types of analyses performed in human genomics studies for cancer. Nanopore sequencing can provide maximum complete information about the healthy human genome in disease states, such as cancer, to:
Variant resolution and epigenetics across the genome
Targeting giant panels or single genes, PCR
Detect known and new complete transcripts, down to the solution of a single cell.
Gordon Sanghera, chief executive of Oxford Nanopore Technologies, commented:
“We are very pleased to welcome clinical researchers from one hundred countries to London this year, who will provide a wide diversity of topics but with a common theme of more complete and faster information. One of the most exciting emerging topics is the expanding use of nanopore sequencing in cancer research; By sequencing local DNA fragments of any length, scientists share how they carry out the exact characterization of a diversity of variants and the integration of fundamental amendment detection. of cancer samples.
We have a wonderful list of consumers who will share their feedback over the next few days and we’re all excited to hear their findings and, more importantly, what’s next. “
Today in London Calling
With an extensive program of 88 conferences covering everything from epigenomics, human genomics, cancer, and transcriptomic research, it’s conceivable to hear from the following researchers:
Euan Ashley will talk about his unprecedented work with ultrafast nanopore genome sequencing in an intensive care setting. in less than 8 hours.
Next, Vanessa Porter will explain how nanopore sequencing is helping to uncover new insights into cervical cancer progression through HPV integration. Using all the functions of Oxford’s nanopore generation to stumble upon new complex structural variants, basic adjustments and transcriptomics, Vanessa sequenced the complete genomes of 66 cervical cancer samples in Uganda and the United States. In sub-Saharan Africa, cervical cancer is the most common type of cancer and the leading cause of cancer mortality, underscoring the importance of this research.
Later in the day, Rosemary Bamford’s presentation will show how her team used Oxford Nanopore transcriptome sequencing to profile transcription diversity in the progression and aging of the human brain. He will show that genes related to neuroprogressive and neurodegenerative disorders are characterized through an abundant diversity of RNA isoforms, and his knowledge will reveal the importance of the splicing of choice in the brain.
The final plenary session will be in charge of Alberto Magi. This is the first study to use high-coverage whole genome nanopore sequencing to analyze genomic and epigenomic alterations in acute myeloid leukemia (AML). This study provides new insights into the genetic mechanisms underlying cancer progression and drug resistance in patients with AML at the time of diagnosis and relapse.
Elsewhere on the agenda, as well as various meetings on genomic surveillance of pathogens, infectious diseases, mobile devices and bioinformatics. from amphibians in Ecuador to the critically endangered kākāpō in New Zealand.
Clive G Brown, CTO of Oxford Nanopore, and colleagues will also provide our update on London call generation at 17:45 BST.
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Contacto:media@nanoporetech. com
About Oxford Nanopore Technologies
The purpose of Oxford Nanopore Technologies is to bring the greatest to society by enabling research into anything, through anyone, anywhere. DNA and ARN. La generation is used in more than 120 countries to perceive the biology of humans and diseases such as cancer, plants, animals, bacteria, viruses and entire environments.
Forward-Looking Statements
This announcement includes certain forward-looking statements. Expressions such as “potential,” “expect,” “intend,” “believe we can,” “work for,” “anticipate,” “once validated” and similar expressions of a prospective or long-term nature may also be taken into account forward-looking statements. Forward-looking statements relate to our long-term planned business and, by definition, relate to issues that, to varying degrees, are uncertain and would possibly involve points beyond our control.
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SOURCE: Oxford Nanopore Technologies plc
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