Without a sieve or a grinder, the production of pharmaceutical tablets is almost impossible. These are mandatory whenever active and inactive tissues are handled, in the manufacture of tablets or other products. Crushing and sieving apparatus are used to reduce the size of the particles.
This serves two purposes: first, it increases the surface area of the particles, which accelerates the degradation process. Second, it equalizes particle length disparities so that the aggregate is homogeneous.
Grinding and sieving apparatus are used in pharmaceutical production because they are versatile.
They can be incorporated into complex production lines, such as filling/emptying activities or transfer to process machines or container filling and sedimentation. The versatility of crushers and screens, as well as the small space occupied by the devices, are discovering points in their use and functionality.
The small size of these devices is especially useful in pharmaceutical cleanrooms, where the area is limited. In addition, several sieving systems and crushers come with built-in lifting columns, allowing them to be incorporated into almost any procedure scenario.
The mobility of the machine is an aspect that improves the efficiency of the procedure. They can be transported or disassembled without problems for use or cleaning.
Crushers and screens, on the other hand, are evolving and improving. In addition to some existing trends, this article explains how the advent of modern hammer generators has increased production efficiency.
Pharmaceutical parts are reduced to consistent sizes using conical sieve machines. They can also be used for mixing, sifting, and dispersing materials. They are available in sizes, adding laboratory apparatus and high-capacity systems.
Compared to the finest grinding technologies on the market, the sieve offers production advantages: it runs quietly, creates a narrow particle size distribution, and provides significant design flexibility and capability.
This indicates that such a screening formula can process low-density fabrics at 50% higher throughput than traditional mills.
The patented Turbo Sieve BTS from L. B. Bohle Maschinen und Verfahren GmbH (Ennigerloh) is used for particle length calibration, in an ideal particle length distribution.
The use of other conical sieves (orifice sieves and friction sieves) makes it possible to process dry and rainy products at speeds ranging from 150 to 1500 revolutions per minute. This makes it possible to achieve product capacities of two to three tons in one hour.
Operators use an easy-to-use 7-inch touchscreen with user management, recipe management, PDF batch print management, and a USB interface. The explosion-proof Turbo Sieve can also be used in programs that require ATEX compliance.
The hygienic design of the sieve facilitates manual erasure. The sieve container can be gently removed from the mixture of the bayonet holder and the clamping ring, making the erasure of each individual component incredibly undeniable.
The sieve housing can be provided with cleaning nozzles for undeniable WIP cleaning, allowing curtain residues to be temporarily removed from the inside of the sieve vessel.
Delivery includes cleaning nozzles on the side walls of the sieve and the angular drive. The cleaning fluid is supplied from a central water source.
Hammer generators (also known as turbogenerators) are ideal for studies and development, batch production, and non-stop manufacturing. They are the length of powders, agglomerates and granules.
Hammer generators are especially used in programs that require precise relief of active chemical particles and other hard-to-grind compounds. They are also used to crush damaged tablets.
Tablets that have already been manufactured are inspected and possibly do not meet the customer’s criteria for various reasons. These criteria come with defects in appearance or lack of proper weight or hardness.
If the pill does not meet the criteria, the manufacturer can re-spray and reuse the fabrics in the hammer mill. In the end, regrinding the pills and recycling the fabrics in production reduces rejection rates and increases productivity.
Hammer mills, such as the L. B. La Bohle Turbo Mill (BTM) series, can produce up to 1,500 kg/h at speeds ranging from six hundred to 6,000 rpm. For this purpose, the BTM includes an automatic dosing unit (rotary feeder).
This allows the operator to introduce the curtains into the crushing chamber lightly and without overloading. In addition, those automatic feeding devices can control the entry of powder into the grinding chamber. Less heat is generated and the procedure can be repeated with the same settings.
The internal rotor has two sides, each with the other for rainy or dry applications. The knife look grinds sticky ingredients and the hammer look breaks hard, crystalline objects.
The length of the screen used in a hammer mill determines the length of the particles. BTM offers a variety of screen inserts that can reduce the length by up to 0. 1mm.
Previously, mobile crop developers used ball generators to reduce the particle length of their first mixes. The ball milling strategy is time-consuming and uses ceramic balls in a rotating drum to weigh products. Once a batch has been processed, the mill and its loads of ceramic beads will need to be cleaned.
This cleaning procedure can take up to a week. During this time, the mill cannot be used and is not available to consumers who require a quick, user-defined batch of powder.
Such a mobile culture manufacturer is looking for a mill that will make it less difficult and more effective to meet the wishes of its biopharmaceutical customers.
They also wanted the mill to be portable and take up little space. The device should be able to be removed from the initial production domain to be cleaned and make room for long-term production processes. The visitor also specified the product. specific specifications, such as temperature, particles and batch size.
Cell cultures require small particle sizes for optimal solution rates. Therefore, up to 50% of the batch will have to be less than one hundred micrometers.
The medium is very resistant to temperatures above 37°C, because the powder stops being bioactive at those temperatures. After market research, the company contacted L. B. Bohle to perform some grinding tests.
KG. The Bohle BTM 150 turbomill produced the specified product length at a throughput of 375 kg/h in a closed bin-to-bin grinding configuration. For the test, Bohle designs a rotor speed of 6,000 rpm on the hammer side.
The turbomill used a 1-millimeter screen, resulting in the same particle length as the ball mill. The BTM provided the highest precision effects desired by the manufacturer.
First they bought a hammer mill, but then they implemented two more. After the mills, the manufacturer has greatly improved its processing efficiency.
Many batches can now be shredded in one week (e. g. e. g. batches of 1,000 kg) instead of one or two batches (using the classic ball grinding process), as the BTM can be disassembled and cleaned temporarily and almost without tools.
KG. Bohle, based in Germany, is one of the largest suppliers of formulations to the pharmaceutical industry and similar sectors. They work internationally on machines and devices, as well as on the generation of procedures and components.
In addition, L. B. Bohle offers sustainable answers for complicated batch and continuous production processes for the production of counterfeit oral doses. For example, L. B. Bohle offers individual or interconnected machines for weighing, dry and rain granulation, grinding and sieving, container mixing, coating and handling processes.
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