KG. Bohle has been a generational leader in all lamination programs for many years. KG. Bohle Coaters promises product processing with maximum cost-effectiveness. It asserts its leading position thanks to continuous progression and patented advantages.
Pharmaceutical film coating is lately a production step in the pharmaceutical sector. The coating generation has evolved over the past few decades, starting with the processing of sugared almonds molds.
Most coating procedures are used to modify the release of the drug, increase its stability to light and moisture, and mask the aroma. In addition, patient compliance issues are crucial, such as swallowing or making it difficult to identify with another color. .
API coating is vital because it allows for combinations of fixed doses or incompatible drug mixtures. Sustained-release coatings, in addition to immediate-release coating layers, can achieve other drug-releasing properties.
Such formulations can involve up to 4 layers of coating, resulting in extended processing periods. Coating uniformity is a necessity and a quality feature for the progression and effective production of such formulations, as coated tablets will have to pass the pharmacopoeia test unit uniformity test. 1,2
Since a coating procedure involves spraying, mixing, and drying simultaneously, setting the proper parameters is to achieve maximum coating uniformity. In recent years, L. B. Bohle has created and improved the design of its coater to meet those needs.
LB Bohle coating technology 3 distinct design elements ensuring optimal coating uniformity.
KG. La geometry of the Bohle tray with an L/D >1 ratio provides a giant bed area, allowing for the use of a large number of spray guns (Figure 1).
Thanks to the higher performance of the coating slurry, processing time can be reduced by up to 40% compared to typical container geometries on the market. In addition, the smaller pickup bed causes minimal cutting in the pads, allowing even the weakest pads to be coated.
The unique helical baffles consist of two layers of baffles (Figure 2). They are responsible for ensuring a consistent and homogeneous axial aggregate within the pellet bed. In addition, drum rotation helps maintain radial aggregate. Both moves Make sure it’s a pill bed with no dead zone.
In this way, after a few minutes, a homogeneous aggregate forms in the tablet bed. Due to the continuous movement of the pill, there are no acceleration spikes, which can cause the pill to break or even break.
LB The top principle of Bohle Film Coaters directs drying capacity where it is needed most: the pellet bed (Figure 3). As a result, the drying capacity of the incoming air is maximized while heating other internal parts of the coater.
The intake air enters the exhaust air funnel directly through the rotating tablet bed from below. Another advantage of this configuration is that the spray guns do not heat the coating and remain cool.
As a result, spray losses are minimized, resulting in coating efficiencies in excess of 95%, which is especially for API coating operations. Beyond the unique qualities that have contributed to L. B. Bohle coating technology, this coating device can be supplied with CIP systems.
At full pressure, a cutting lance is used to leave the coating machine blank after production in automated mode.
KG. Bohle coating devices are available in different sizes, from experiments to large-scale production. In addition, various configuration lines are available on all continents to meet different customer wishes. In addition to the classic types of batch devices, semi-continuous coaters are also available.
KG. Bohle, headquartered in Germany, is one of the largest suppliers of systems for the pharmaceutical industry and similar industries. They are active all over the world and concentrate on machinery and apparatus as well as on process and component generation.
Furthermore, L. B. Bohle offers sustainable answers for the difficult batch and continuous production processes for the production of counterfeit oral doses. For example, L. B. Bohle offers individual or interconnected machines for weighing, dry and rain granulation, grinding and sieving, container mixing, coating and handling processes.
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